Use of Extra Virgin Olive Oil (EVOO) in the treatment of traumatic ulcers. A case report

##plugins.themes.bootstrap3.article.main##

Antonia Sinesi
Cinzia Casu
Savino Cefola
Ruggiero Damato
Germano Orrù

Abstract

Introduction


Extra virgin olive oil (EVOO) is an essential food of the Mediterranean diet (MD) and some countries in the Mediterranean area such as Italy, Spain and Greece represent the largest and most important producers in the world. In Southern Italy, precisely all through the countryside of the north of Bari in Apulia, is produced a particular type of extra virgin olive oil by cultivar "Coratina" characterized by the presence of a high content of polyphenols, the highest compared to other cultivars (1) and very rich in biocompounds.


Since the last century, it was customary for the inhabitants of the area to use it for the treatment of various diseases: burns, trauma, cheilitis and processes inflammation of various kinds. Over time, this practice has gradually disappeared and almost forgotten.


In recent decades, numerous studies have been published which have documented most of the beneficial effects of the Mediterranean diet in promoting human health.


Its beneficial effects can largely be attributed to the consumption of extra virgin olive oil (EVOO) (2). The consumption of extra virgin olive oil is able to reduce lipid and DNA oxidation, improve the lipid profile and insulin resistance, endothelial dysfunction, inflammation, reduce blood pressure in hypertensive patients and modify the response of the immune system (3, 4).


Despite its extensive use and although numerous studies on extra virgin olive oil have shown its remarkable effectiveness in healing skin burns (5, 6, 7), bedsores (8) and foot wounds in the diabetic patient (9), no scientific studies have been proposed for the treatment of traumatic ulcers in the oral cavity.


In this case - report, we decided to use EVOO as a therapeutic aid in the treatment of mucosal oral injury in a prosthesis on implant-bearer patient.


Key words: extra virgin olive oil, polyphenols, “Coratina” cultivar, traumatic ulcers.

Downloads

I dati di download non sono ancora disponibili

##plugins.themes.bootstrap3.article.details##

Come citare
Sinesi, A., Casu, C., Cefola, S., Damato, R., & Orrù, G. (2020). Use of Extra Virgin Olive Oil (EVOO) in the treatment of traumatic ulcers. A case report. Journal of Biomedical Practitioners, 4(1). https://doi.org/10.13135/2532-7925/4646
Sezione
Articoli

Riferimenti bibliografici

[1] Del Coco L, De Pascali SA, Fanizzi FP (1) H NMR Spectroscopy and Multivariate Analysis of Monovarietal EVOOs as a Tool for Modulating Coratina-Based Blends. Foods. 2014; 3:238–249.
doi: 10.3390/foods3020238.
[2] Trichopoulou A, Martinez-Gonzalez MA, Tong TY et al. Definitions and potential health benefits of the Medi-terranean diet: views from experts around the world. BMC Med. 2014; 12:112.
doi: 10.1186/1741-7015-12-112.
[3] Sales-Campos H, Souza PR, Peghini BC et al. An overview of the modulatory effects of oleic acid in health and disease. Mini Rev Med Chem. 2013 Feb; 13(2):201-10. Review.
[4] Gaforio JJ, Visioli F, Alarcón-de-la-Lastra C et al. Virgin Olive Oil and Health: Summary of the III Inter-national Conference on Virgin Olive Oil and Health Consensus Report, JAEN (Spain) 2018. Nutrients. 2019 Sep 1;11(9). pii: E2039.
doi: 10.3390/nu11092039.
[5] Edraki M, Akbarzadeh A, Hosseinzadeh M et al. Healing effect of sea buckthorn, olive oil, and their mixture on full-thickness burn wounds. Adv Skin Wound Care. 2014 Jul; 27(7):317-23.
doi: 10.1097/01.ASW.0000451061.85540.f9.
[6] Sánchez-Quesada C, López-Biedma A, Toledo E et al. Squalene Stimulates a Key Innate Immune Cell to Fos-ter Wound Healing and Tissue Repair. Evid Based Complement Alternat Med. 2018 Sep 30;2018:9473094.
doi: 10.1155/2018/9473094. eCollection 2018.
[7] Lin TK, Zhong L, Santiago JL. Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils 0Int J Mol Sci. 2017 Dec 27; 19(1). pii: E70.
doi: 10.3390/ijms19010070. Review.
[8] Cochrane Database of Systematic Reviews. Dressings and topical agents for preventing pressure ulcers Cochrane Systematic Review - Intervention Version published: 06 December 2018
[9] Karimi Z, Behnammoghadam M, Rafiei H et al. Impact of olive oil and honey on healing of diabetic foot: a randomized controlled trial Clin CosmetInvestig Dermatol. 2019 May 9;12:347-354.
doi: 10.2147/CCID.S198577. eCollection 2019.
[10] Tripoli E, Giammanco M, Tabacchi G et al.La Guardia M. The phenolic compounds of olive oil: Structure, bi-ological activity and beneficial effects on human health. Nutr. Res. Rev. 2005; 18:98–112.
doi: 10.1079/NRR200495
[11] Yubero-Serrano EM, Lopez-Moreno J, Gomez-Delgado F et al. Extra virgin olive oil: More than a healthy fat. Eur. J. Clin. Nutr. 2019; 72:8–17.
doi: 10.1038/s41430-018-0304-x.
[12] Ranalli F, Ranalli A, Contento S et al. Bioactives and nutraceutical phytochemicals naturally occurring in virgin olive oil. The case study of the Nocellara del Belice Italian olive cultivar. Nat.Prod.Res. 2013; 27:1686–1690. doi: 10.1080/14786419.2012.762918.
[13] Gorzynik-Debicka M, Przychodzen P, Cappello F et al. Potential Health Benefits of Olive Oil and Plant Poly-phenols.Int J Mol Sci. 2018 Feb 28;19(3). pii: E686.
doi: 10.3390/ijms19030686.
[14] Correa JA, Lopez-Villodres JA, Asensi R et al. Virgin olive oilpolyphenolhydroxytyrosol acetate inhibits in vitro platelet aggregation in human whole blood: Comparison with hydroxytyrosol and acetylsalicylic acid. Br. J. Nutr. 2009; 101:1157–1164.
doi: 10.1017/S0007114508061539.
[15] Virruso C, Accardi G, Colonna-Romano G et al. Nutraceutical properties of extra-virgin olive oil: A natural remedy for age-related disease? Rejuvenation Res. 2014; 17:217–220.
doi: 10.1089/rej.2013.1532
[16] Beauchamp GK, Keast RS, Morel D et al. Phytochemistry: Ibuprofen-like activity in extra-virgin olive oil. Nature. 2005; 437:45–46.
doi: 10.1038/437045a.
[17] Yadav TC, Kumar N, Raj U et al. Exploration of interaction mechanism of tyrosol as a potent anti-inflammatory agent. JBiomol Struct Dyn. 2020 Feb;38(2):382-397.
doi: 10.1080/07391102.2019.1575283. Epub 2019 Mar
[18] Monti SM, Ritieni A, Sacchi R et al. Characterization of phenolic compounds in virgin olive oil and their ef-fect on the formation of carcinogenic/mutagenic heterocyclic amines in a model system. J. Agric. Food Chem. 2001; 49:3969–3975.
doi: 10.1021/jf010240d.
[19] Ichihashi M, Ahmed NU, Budiyanto A et al. Preventive effect of antioxidant on ultraviolet-induced skin can-cer in mice. J Dermatol Sci 2000; 23(suppl 1):S45-S50.
[20] Kiechl-Kohlendorfer U, Berger C, Inzinger R. The effect of daily treatment with an olive oil/lanolin emol-lient on skin integrity in preterm infants: a randomized controlled trial. Pediatr Dermatol 2008; 25:174-178.
[21] Cui Z, Xin M, Yin H et al. Topical use of olive oil preparation to prevent radiodermatitis: results of a pro-spective study in nasopharyngeal carcinoma patients. Int J ClinExpMed 2015; 8:11000-11006.
[22] Fancello F, Multineddu C, Santona M et al. Bacterial Biodiversity of Extra Virgin Olive Oils and Their Poten-tial Biotechnological Exploitation. Microorganisms. 2020 Jan 10; 8(1). pii: E97.
doi: 10.3390/microorganisms8010097.
[23] De Santis S, Cariello M, Piccinin E et al. Extra Virgin Olive Oil: Lesson from NutrigenomicsNutrients. 2019 Sep 4; 11(9). pii: E2085.
doi: 10.3390/nu11092085.
[24] Minhas S, Sajjad A, Kashif M et al. Oral Ulcers Presentation in Systemic Diseases: An Update. Open Access Maced J Med Sci. 2019 Oct 10; 7(19):3341-3347.
doi: 10.3889/oamjms.2019.689. eCollection 2019 Oct 15.